Endogenous pyrogen-like substance produced by reptiles.

Endogenous Pyrogen

Abs t rac t -The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-I) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/IL-1 does not appear to explain the diminished febrile response...

Synthesis of Endogenous Pyrogen by Rabbit Leukocytes

Rabbit ieukocytes from peritoneal exudates and from blood were stimulated to form leukocyte pyrogen in the presence of radiolabeled amino acids. The stimuli used were endotoxin, phagocytosis, and tuberculin. The crude leukocyte pyrogen samples were purified; pyrogen from exudate cells was rendered homogeneous; pyrogen from blood cells was still contaminated with other proteins. All the purified...

Characteristics of a bacteriocin -like substance produced by Clostridium haemolyticum strain IRP - 135

Differentiation between endogenous pyrogen and leukocytic endogenous mediator.

The crude material released from glycogen-stimulated rabbit peritoneal polymorphonuclear leukocytes when administered to experimental animals elicits a number of metabolic and physiologic alterations characteristic of those observed in the host inflammatory response. Classically, the mediator of febrile response observed in rabbits and other species has been termed endogenous pyrogen (EP), wher...

Purification and characterization of an endogenous pyrogen.

Many microbes and their products are capable of producing fever when injected intravenously in various laboratory animals. Recent studies, involving passive transfer of serum from febrile donor animals to normal recipients, have shown that most, if not all, these agents cause fever indirectly via liberation of a circulating pyrogen of endogenous origin.' To date, the source of endogenous pyroge...